Photobiomodulation
Research & Studies
Research from Mass General, Harvard, Boston University & More
The studies below examine photobiomodulation (PBM) — the use of red and near-infrared light to influence cellular activity at the mitochondrial level. For a full explanation of how the mechanism works and where the field came from, see our main photobiomodulation guide; this page focuses on the underlying research itself.
The collection spans laboratory, animal, and clinical work across a range of applications, from skin and tissue repair to pain and cellular function. It is drawn from peer-reviewed sources and is organized so you can trace individual findings back to their original publications.
The evidence base is broad but uneven. Results vary considerably by condition, wavelength, dose, and study design — some applications are supported by controlled clinical trials, while others remain preliminary, conflicting, or limited to preclinical models. Rather than presenting only favorable outcomes, the collection below reflects that full range, including reviews that report mixed or negative findings. We believe an honest picture of the science is more useful than a selective one.
This library is maintained and periodically reviewed by our clinical team to keep it current as new research is published.
Explore Skin & Aesthetics
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
Is light-emitting diode phototherapy (LED-LLLT) really effective?
Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo
Green light emitting diodes accelerate wound healing: characterization of the effect and its molecular basis in vitro and in vivo
Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing
Explore Nerve Function & Repair
“Quantum Leap” in Photobiomodulation Therapy Ushers in a New Generation of Light-Based Treatments for Cancer and Other Complex Diseases: Perspective and Mini-Review
Explore Energy / Mitochondrial Function
Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy
PMID: 16120414
Biphasic dose response in low level light therapy
PMID: 20011653